Anti-TNF therapy






Study overview

  • Figure shows absolute benefit/risk. This is calculated by assessing benefit/risk of study drug against placebo, except where stated
  • Multicenter, double-blind, randomized, placebo-controlled trial
  • Evaluated the efficacy of infliximab maintenance therapy in 306 adult patients with Crohn's disease and one or more draining abdominal or perianal fistulas of at least three months' duration
  • Patients received 5 mg of infliximab per kilogram of body weight intravenously on weeks 0, 2, and 6
  • 195 patients who had a response at weeks 10 and 14 (initial responders) and 87 patients who had no response (initial non-responders) were then randomly assigned to receive placebo or 5 mg of infliximab per kilogram every eight weeks and to be followed to week 54

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